META-ANALYSIS OF MCP-1 GENE POLYMORPHISM AND INCIDENCE OF DIABETIC NEPHROPATHY IN THE ASIAN POPULATION

Background: Diabetes poses a serious threat to global public health, and it has a severe impact on people's health. In the development of diabetic nephropathy, monocyte chemoattractant protein-1 is considered as a pathogenic agent, as well as it is a robust stimulating factor for macrophage recruitment. Methods: At present, in the MCP-1 gene, we have found polymorphic genes, and the A-2518 G polymorphism in the MCP-1 promoter region is considered to be an essential factor for regulating gene expression and affecting plasma MCP-1 concentration. Some studies have shown that the occurrence of kidney disease is associated with the MCP-1 A-2518 G gene. Results: So, we speculate that MCP-1-2518, A / G gene polymorphism can affect diabetes and kidney disease. In this meta-analysis, we have total of nine studies including four Chinese people related, four Indian people related, two Korean people related and one Turkish people described. Conclusion: The analysis showed that it was not obvious to address the correlation between diabetic nephropathy and GG genotype in China, Korea, and Turkey. However, in Indian people, the GG genotype is related to a reduced risk of diabetic nephropathy (p<0.05). From the study of diabetic nephropathy, it was hard to find out significant correlations between G alleles and AA genotypes among people in China, Korea, Turkey, and India. Therefore, among people in China, Korea, and Turkey, we preliminarily concluded that there is no apparent interaction between the MCP-1 A-2518G gene polymorphism and the risk of diabetic nephropathy. However, among Indians, GA genotype has an essential impact on the occurrence of diabetic nephropathy (p<0.05).