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The biosynthetic gene cluster of the C -nucleoside antibiotic pyrazomycin with a rare pyrazole moiety

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Abstract

Pyrazomycin is a rare -nucleoside antibiotic with a naturally occurring pyrazole ring, whose biosynthetic origin has remained obscure for decades. In this study, we report the identification of the gene cluster responsible for pyrazomycin biosynthesis in NRRL 3601, revealing that StrR-family regulator PyrR is the cluster-situated transcr...More

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Author
Guiyun Zhao
Guiyun Zhao
Shunyu Yao
Shunyu Yao
Kristina W Rothchild
Kristina W Rothchild
Tengfei Liu
Tengfei Liu
Hai-Yan He
Hai-Yan He
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