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Impact of CD34 Cell Dose and Conditioning Regimen on Outcomes after Haploidentical Donor Hematopoietic Stem Cell Transplantation with Post-Transplantation Cyclophosphamide for Relapsed/Refractory Severe Aplastic Anemia.

Biology of Blood and Marrow Transplantation(2020)

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摘要
•Hematopoietic stem cell transplantation from haploidentical donors for relapsed/refractory severe aplastic anemia is feasible.•Primary graft failure was 15%, 2-year event-free survival (EFS) was 70%, and 2-year overall survival was 79%.•An augmented cyclophosphamide/fludarabine/total body irradiation regimen is associated with improved EFS.•A CD34 cell dose >3.2 × 10E6/kg is associated with improved EFS.
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关键词
Haploidentical,Aplastic anemia,Alternativo donors
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