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A unified view of neighbour cell engagement during apoptotic cell extrusion

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Epithelia must eliminate apoptotic cells to preserve tissue barriers and prevent inflammation []. Several different mechanisms exist for apoptotic clearance, including efferocytosis [, ] and apical extrusion [, ]. We found that extrusion was the first-line response to apoptosis in cultured monolayers and in zebrafish epidermis. During ext...More

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