Characterization of viral insulins reveals white adipose tissue-specific effects in mice

Martina Chrudinová,François Moreau,Hye Lim Noh,Terezie Páníková,Lenka Žáková,Randall H. Friedline,Francisco A. Valenzuela,Jason K. Kim,Jiří Jiráček,C. Ronald Kahn,Emrah Altindis

Molecular Metabolism（2021）

引用 13|浏览27

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摘要

•Viral insulin/IGF1-like peptides (VILPs) are microbial members of the insulin superfamily.•VILPs bind to human IR and IGF1R and stimulate post-receptor signaling.•Grouper iridovirus (GIV) VILP has white adipose tissue (WAT)-specific characteristics.•GIV VILP stimulates increased glucose uptake in WAT via increased GLUT4 expression.

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关键词

VILPs,Viral insulin,Insulin,IGF-1,GLUT4,Adipose tissue,Glucose metabolism,Viral mimicry

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