Active Perception during Angiogenesis: Filopodia speed up Notch selection of tip cells in silico and in vivo
biorxiv(2020)
摘要
We first validate simulation predictions with live imaging of zebrafish intersegmental vessel growth. Further simulation studies then indicate the effect is due to the coupled positive feedback between movement and sensing on filopodia conferring a bistable switch-like property to Notch lateral inhibition, ensuring tip selection is a rapid and robust process. We then employ measures from computational neuroscience to assess whether filopodia function as a primitive (‘basal’) form of active perception and find evidence in support. By viewing cell behaviour in tissues through the ‘basal cognitive lens’ we acquire a fresh perspective on not only the well-studied tip cell selection process, revealing a hidden, yet vital, time-keeping role for filopodia, but on how to interpret and understand cell behaviour in general, opening up a myriad of new and exciting research directions.
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关键词
Angiogenesis,Active Perception,Basal Cognition,Morphogenesis,Notch Lateral Inhibition,Filopodia
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