Chiral evasion and stereospecific antifolate resistance in Staphylococcus aureus

Siyu Wang
Siyu Wang
Adegoke A. Ojewole
Adegoke A. Ojewole
Marcel S. Frenkel
Marcel S. Frenkel
Graham T. Holt
Graham T. Holt
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Abstract:

Antimicrobial resistance is a health care crisis. The resistance-conferring mutation F98Y in dihydrofolate reductase (SaDHFR) reduces effectiveness of antifolates, e.g., trimethoprim (TMP). Although propargyl-linked antifolates (PLAs) are much more resilient than TMP towards F98Y, this substitution still vitiates their inhibition potency...More

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