Deficits in Behavioral and Neuronal Pattern Separation in Temporal Lobe Epilepsy

A.D. Madar
A.D. Madar
J.A. Pfammatter
J.A. Pfammatter
J. Bordenave
J. Bordenave
E.I. Plumley
E.I. Plumley
S. Ravi
S. Ravi
M. Cowie
M. Cowie
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Abstract:

In temporal lobe epilepsy, the ability of the dentate gyrus to limit excitatory cortical input to the hippocampus breaks down, leading to seizures. The dentate gyrus is also thought to help discriminate between similar memories by performing pattern separation, but whether epilepsy leads to a breakdown in this neural computation, and thus...More

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