Pharmacological depletion of microglia prevents vascular cognitive impairment in Ang II-induced hypertension

Danielle Kerkhofs,Britt T. van Hagen,Irina V. Milanova,Kimberly J. Schell,Helma van Essen,Erwin Wijnands,Pieter Goossens,W. Matthijs Blankesteijn,Thomas Unger,Jos Prickaerts,Erik A. Biessen,Robert J. van Oostenbrugge,Sebastien Foulquier

biorxiv（2020）

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摘要

Our results show that depletion of microglia, and less so PVMs, by CSF1R inhibition prevents short-term memory impairment in Ang II induced hypertensive mice. This novel finding supports the critical role of brain immune cells, and most in particular microglia, in the pathogenesis of hypertension-related cognitive impairment.

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关键词

vascular cognitive impairment,microglia,cognitive impairment,hypertension,pharmacological depletion,ii-induced

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