Zinc Determines Dynamical Properties and Aggregation Kinetics of Human Insulin

K. Pounot
K. Pounot
G. W. Grime
G. W. Grime
A. Longo
A. Longo
D. Noferini
D. Noferini
V. Cristiglio
V. Cristiglio
M. Weik
M. Weik
V. Foderà
V. Foderà
G. Schirò
G. Schirò

Biophysical journal, pp. 1-40, 2021.

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Abstract:

Protein aggregation is a widespread process leading to deleterious consequences in the organism, with amyloid aggregates being important not only in biology but also for drug design and biomaterial production. Insulin is a protein largely used in diabetes treatment and its amyloid aggregation is at the basis of the so-called insulin-deriv...More

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