A Mesoscale Finite Element Modeling Approach For Understanding Brain Morphology And Material Heterogeneity Effects In Chronic Traumatic Encephalopathy
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING(2021)
摘要
Chronic Traumatic Encephalopathy (CTE) affects a significant portion of athletes in contact sports but is difficult to quantify using clinical examinations and modeling approaches. We use an in silico approach to quantify CTE biomechanics using mesoscale Finite Element (FE) analysis that bridges with macroscale whole head FE analysis. The sulci geometry produces complex stress waves that interact with one another to create increased shear stresses at the sulci depth that are significantly larger than in analyses without sulci (from 0.5 to 18.0 kPa). Sulci peak stress concentration regions coincide with experimentally observed CTE sites documented in the literature.
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关键词
Mesoscale modeling, multiscale modeling, chronic traumatic encephalopathy, sulci, traumatic brain injury, American football
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