Response To Anti-Pd-1 In Microsatellite-Stable Colorectal Cancer: A Stat Need

CLINICAL CANCER RESEARCH(2020)

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摘要
Most colorectal cancers are microsatellite-stable with no response to anti-PD-1 therapy, necessitating the development of new immunomodulatory treatment strategies. Coinhibition of anti-PD-1 and STAT3 can elicit an effective antitumor response in a small subset of patients with microsatellite-stable colorectal cancer, and biomarkers predictive of response are under investigation.
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