Identification Of Clonal Skin Myeloid Cells By Next-Generation Sequencing In Myelodysplasia Cutis (Vol 184, Pg 367, 2021)

Myelodysplastic syndromes (MDS) are malignant hematopoietic stem cell disorders characterized by dysplastic and ineffective blood cell production leading to blood cytopenias, and a risk of transformation to acute myeloid leukemia (AML). Skin lesions in patients with MDS include Sweet syndrome (SS), leucocytoclastic vasculitis, leukemia cutis and histiocytoid SS (H-SS), among others,.1,2 H-SS is a histological variant of SS differing from classical neutrophilic SS by a dermal infiltrate mostly made of immature cells of the myeloid lineage, that has been associated with myeloid malignancies.