Deficiency in Insulin‐like Growth Factors Signalling in Mouse Leydig Cells Increase Conversion of Testosterone to Estradiol Because of Feminization

A growing body of evidence pointed correlation between insulin‐resistance, testosterone level and infertility, but there is scarce information about mechanisms. The aim of this study was to identify the possible mechanism linking the insulin‐resistance with testosterone‐producing‐Leydig‐cells functionality.