miR-129-5p alleviates LPS-induced acute kidney injury via targeting HMGB1/TLRs/NF-kappaB pathway

Xin Huang, Xiangping Hou,Libo Chuan, Shutao Wei,Jingrong Wang,Xiaohua Yang,Jin Ru

International Immunopharmacology（2020）

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摘要

•miR-129-5p is decreased in septic mice.•HMGB1 is a direct target of miR-129-5p.•Agomir-miR-129-5p improves survival in septic mice.•Agomir-miR-129-5p attenuates sepsis-induced AKI.

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关键词

Sepsis,Acute kidney injury,microRNA,Inflammation,HMGB1

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