Evaluation of Triggers of Status Migrainosus and its impact on morbidity

Objective: We tried to analyze the prevalence trend of SM, assess the risk factors to identify potential triggers and morbidity predictors for SM. Background: Status migrainosus (SM) is usually resistant to standard migraine medications and leads to a large proportion of migraine hospitalizations. Design/Methods: We performed a population-based retrospective cross-sectional analysis of Nationwide Inpatient Sample (years 2003–2014) in adult (\u003e18-years) hospitalizations for status migrainosus(and intractable migraine) using ICD-9-CM code. Morbidity was defined by hospital stay \u003e5days(\u003e90 percentile of mean migraine hospitalizations) and discharge other than home(short-term hospitals/skilled nursing facility/home health care/intermediate care facility). We performed weighted univariate analysis using chi-square test, paired t-test, and cochran-armitage trend test. We performed weighted multivariate survey logistic regression analyses to evaluate the triggers of SM and predictors of SM-related morbidity. Results: A total of 446,446 US hospitalizations had a primary diagnosis of migraine. Out of these, 130,914(29.32%) patients had SM. There was a significant increase in the prevalence of SM in the migraineurs (2003:27.49% to 2014:32.68%; pTrend Conclusions: The study reveals triggers for SM and shows higher morbidity associated with SM. Early identification and management of triggers may help mitigate the burden of SM. Disclosure: Dr. Patel has nothing to disclose. Dr. Lavado has nothing to disclose. Dr. Shah has nothing to disclose. Dr. Malik has nothing to disclose. Dr. Hussain has nothing to disclose. Dr. Bhatnagar has nothing to disclose. Dr. Kapoor has nothing to disclose. Dr. Arumaithurai has nothing to disclose. Dr. Kavi has nothing to disclose.