Antitumor activity of lurbinectedin in second-line small cell lung cancer patients who are candidates for re-challenge with the first-line treatment

•The NCCN recommends first-line re-challenge for relapsed SCLC with CTFI ≥ 180 days.•This recommendation is based on data from small trials from the 1980s.•Lurbinectedin has remarkable activity and acceptable safety in second-line SCLC.•ORR was 60.0 % in a preplanned subset of patients with CTFI ≥ 180 days.•Lurbinectedin can be a valuable alternative to re-treatment with first-line therapy.