Health-related quality of life in Cuban patients with chronic liver disease: A real-world experience

•Patient reported outcomes (PROs) are important to understanding the impact a disease from the patients’ point of view.•Chronic liver disease (CLD) can carry a high clinical and PRO burden.•PRO data are few among patients with CLD who reside in the Latin America and the Caribbean areas.•Using valid and reliable PRO instruments, we quantified PROs for patients with CLD living in Cuba.•We determined that patients from Cuba with hepatitis C virus and autoimmune liver disease had the worst PRO scores most likely related to more severe underlying liver disease (fibrosis) and/or to extrahepatic manifestations (fatigue, abdominal pain, anxiety, and depression).