Effects Of Integrase Inhibitor-Based Art On The Nlrp3 Inflammasome Among Art-Naive People With Hiv

Mabel Toribio,Tricia H Burdo,Evelynne S Fulda,Madeline Cetlin,Sarah M Chu,Meghan N Feldpausch,Gregory K Robbins,Tomas G Neilan,Kathleen Melbourne,Steven K Grinspoon,Markella V Zanni

OPEN FORUM INFECTIOUS DISEASES（2020）

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摘要

The NOD-like receptor protein family pyrin domain containing 3 (NLRP3) inflammasome, activated in the setting of HIV, contributes to pro-atherogenic inflammation. Among antriretroviral therapy-naive people with HIV (vs controls), levels of caspase-1-a key component of the NLRP3 inflammasome-were significantly increased. Six months of elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate significantly decreased caspase-1 levels in association with CD4+/CD8+ ratio recovery.

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关键词

atherosclerosis, cardiovascular disease, caspase-1, HIV, NLRP3 inflammasome, pyroptosis

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