Long-term porcine islet graft survival in diabetic non-human primates treated with clinically available immunosuppressants.
XENOTRANSPLANTATION(2020)
摘要
BACKGROUND:Although pancreatic islet transplantation is becoming an effective therapeutic option for patients with type 1 diabetes (T1D) who suffer from a substantially impaired awareness of hypoglycemia, its application is limited due to the lack of donors. Thus, pig-to-human islet xenotransplantation has been regarded as a promising alternative due to the unlimited number of "donor organs." Long-term xenogeneic islet graft survival in pig-to-non-human primate (NHP) models has mainly been achieved by administering the anti-CD154 mAb-based immunosuppressant regimen. Since the anti-CD154 mAb treatment has been associated with unexpected fatal thromboembolic complications in clinical trials, the establishment of a new immunosuppressant regimen that is able to be directly applied in clinical trials is an urgent need.
METHODS:We assessed an immunosuppressant regimen composed of clinically available agents at porcine islet transplantation in consecutive diabetic NHPs.
RESULTS:Porcine islet graft survival in consecutive diabetic NHPs (n = 7; >222, >200, 181, 89, 62, 55, and 34 days) without severe adverse events.
CONCLUSION:We believe that our study could contribute greatly to the initiation of islet xenotransplantation clinical trials.
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关键词
clinically available immunosuppressants, diabetes mellitus, non‐, human primate, porcine islet transplantation
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