Cholesterol metabolites and plant sterols in cerebrospinal fluid are associated with Alzheimer’s cerebral pathology and clinical disease progression

This graphical abstract shows the most important associations between non-cholesterol sterols, oxysterols and Alzheimers’ disease (AD) pathologys’ core biomarkers, as well as associations between sterols and clinical scores. On the right side the individual associations are displayed by bidirectional arrows between the sterols and the biomarkers. We present associations of CSF desmosterol with Aß1−42 and of CSF campesterol with tau and sitosterol with tau and p-tau. Additionally, we show associations of CSF 24S−OHC with tau and p-tau and between the ratio of 24S−OHC/ 27−OHC with tau and p-tau. On the left side the impact of desmosterol on the scores of CDRSoB and MMSE are indicated. As well as the influence of the ratio of 24S−OHC to 27−OHC on score changes of CDRSoB and of the plant sterols, campesterol and sitosterol, on the score changes of MMSE.