Advanced Prostate Cancer with ATM Loss: PARP and ATR Inhibitors

European Urology（2021）

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摘要

ATM loss can be detected by immunohistochemistry (IHC) in 10% of advanced prostate cancers; it associates with genomic instability and sensitivity to combined PARP and ATR inhibition in preclinical prostate cancer models. Prospective studies should compare the clinical predictive value of IHC versus next-generation sequencing assays for DNA repair targeting agents.

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关键词

Prostate cancer,ATM,DNA damage response,Synthetic lethality,PARP inhibition,ATR inhibition

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