Pulmonary Adenocarcinomas Of Low Malignant Potential Proposed Criteria To Expand The Spectrum Beyond Adenocarcinoma In Situ And Minimally Invasive Adenocarcinoma
AMERICAN JOURNAL OF SURGICAL PATHOLOGY(2021)
摘要
Lung cancer screening has improved mortality among high-risk smokers but has coincidentally detected a fraction of nonprogressive adenocarcinoma historically classified as bronchoalveolar carcinoma (BAC). In the National Lung Screening Trial (NLST) the majority of BAC-comprising 29% of computed tomography-detected stage I lung adenocarcinoma-were considered overdiagnosis after extended follow-up comparison with the control arm. In the current classification, adenocarcinoma in situ and minimally invasive adenocarcinoma have replaced BAC but together comprise only similar to 5% of stage I lung adenocarcinoma. Lepidic and subsets of papillary and acinar adenocarcinoma also infrequently recur. We, therefore, propose criteria for low malignant potential (LMP) adenocarcinoma among nonmucinous adenocarcinoma measuring <= 3 cm in total, exhibiting >= 15% lepidic growth, and lacking nonpredominant high-grade patterns (>= 10% cribriform, >= 5% micropapillary, >= 5% solid), >1 mitosis per 2 mm(2), angiolymphatic or visceral pleural invasion, spread through air spaces or necrosis. We tested these criteria in a multi-institutional cohort of 328 invasive stage I (eighth edition) and in situ adenocarcinomas and observed 16% LMP and 7% adenocarcinoma in situ/minimally invasive adenocarcinoma which together (23%) approximated the frequency of overdiagnosed stage I BAC in the NLST. The LMP group had 100% disease-specific survival. The proposed LMP criteria, incorporating multiple histologic parameters, may be a clinically useful "low-grade" prognostic group. Validation of these criteria in additional retrospective cohorts and prospective screen-detected cohorts should be considered.
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关键词
indolent lung cancer, overdiagnosis, histologic criteria lung adenocarcinoma
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