Chronic Lurasidone Treatment in Stress-Based Models of Psychiatric Disorders: From Prevention to Functional Normalization

Exposure to stress in different periods of life represents a risk factor for the development of psychiatric disorders. Here we used two different experimental paradigms, the prenatal stress (PNS) model and the chronic mild stress (CMS) model to identify brain alterations caused by exposure to stress early in life or at adulthood, and to investigate the ability of the antipsychotic drug lurasidone to prevent or counteract the stress-induced abnormalities.