Resting State Functional Connectivity of the Reward System and Outcomes in Psychotherapies for Late-Life Depression

Problem solving therapy (PST) and “Engage”, a reward-exposure” based therapy, are important treatment options for late-life depression (LLD), given modest efficacy of antidepressants in this disorder. Abnormal function of reward networks has been observed during depressive episodes. This study examined whether resting state functional connectivity (rsFC) of reward circuitries is associated with treatment outcomes.