Involvement of a Locus Coeruleus-to-Prefrontal (LC-mPFC) Circuit in a Touchscreen Variant of the Continuous Performance Test (CPT) in Mice

Sustained attention is disrupted in a variety of neuropsychiatric disorders, including schizophrenia and attention deficit hyperactivity disorder (ADHD). Much research suggests that interregional communication between subcortical brain areas (i.e., basal forebrain, ventral tegmental area, locus coeruleus) and the PFC may contribute to attention-directed behavior. The exact role of these circuits in sustained attention, however, remains unclear.