Cortical Gamma as a Marker of Kynurenine Pathway Engagement in Healthy Veterans Receiving L-4-Chloro-Kynurenine (AV-101)

Medically severe suicide attempts are increasing amongst the civilian population, and persistently elevated in veterans. Suicidality has been linked with abnormal NMDA Receptor function stemming from dysfunction of the kynurenine pathway. In this Phase 1b trial, we investigated the dose-response relationship of the investigational drug AV-101 (L-4-chloro-kynurenine) and a known marker of NMDAR function: the 40 Hz auditory steady state gamma amplitude.