Synthesis and antiproliferative activity of new chlorin e6 glycoconjugates

Natalia S. Kuzmina,Vasilii F. Otvagin, Lubov V. Krylova,Alexander V. Nyuchev, Yuliya V. Romanenko,Oscar I. Koifman,Irina V. Balalaeva,Alexey Yu. Fedorov

Mendeleev Communications（2020）

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摘要

New water soluble conjugates of chlorin e6 derivative–zinc complex with β-d-galactose or β-d-glucose have been synthesized as potential agents for the photodynamic therapy of cancer. They exhibit photoinduced cytotoxicity at low micromolar concentrations with IC50(dark)/IC50(light) ratio of ∼50.

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关键词

chlorin e6,glycoconjugate,water soluble,A431 cells,photodynamic therapy

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