Tu1478 NOVEL HEMOSTATIC POWDER STOPS BLEEDING IN A LIVE PROCINE MODEL OF UPPER GASTROINTESTINAL BLEEDING

Hemostatic powders are an attractive option in upper gastrointestinal bleeding (UGIB). However, currently available powders are not effective in Forrest Class 1a bleeds and are associated with unacceptably high rebleeding rates. These limitations are related to their mechanism of action which is based on provision of a mechanical bandage on, rather than delivery of any therapeutic agents to, the site of injury. A novel hemostatic powder that self-propels cargo has been developed that effectively delivers thrombin (propelled thrombin) against blood flow and into the site of injury.