Immune landscape and biomarkers for immune-oncology in colorectal cancers.
JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE(2020)
摘要
Recent advances in immuno-oncology have increased understanding of the tumor immune microenvironment (TIME), and clinical trials for immune checkpoint inhibitor treatment have shown remission and/or durable response in certain proportions of patients stratified by predictive biomarkers. The TIME in colorectal cancer (CRC) was initially evaluated several decades ago. The prognostic value of the immune response to tumors, including tumor-infiltrating lymphocytes, peritumoral lymphoid reaction, and Crohn's-like lymphoid reaction, has been well demonstrated. In this review, we describe the chronology of TIME research and review the up-to-date high-dimensional TIME landscape of CRC. We also summarize the clinical relevance of several biomarkers associated with immunotherapy in CRC, such as microsatellite instability, tumor mutational burden, POLE/POLD mutation, consensus molecular subtype, and programmed death-ligand 1 expression.
更多查看译文
关键词
Colorectal neoplasms,Tumor immune microenvironment,Immunotherapy,Microsatellite instability
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络