Study on the Role of Paclitaxel Nano-Drug Delivery System in Inhibiting Intimal Hyperplasia and Improving Vascular Remodeling in Abdominal Aortic Injury Model.

The surface-modified paclitaxel nanoparticles were prepared to observe its inhibitory effect on the intimal and mediator proliferation and the improvement of vascular remodeling after rabbit abdominal aortic injury. First, paclitaxel nanoparticles were prepared by ultrasonic emulsification solvent evaporation method. The surface of paclitaxel nanoparticles was modified by physical adsorption, the nanoparticles were characterized and the encapsulation efficiency was evaluated. Secondly, the endometrial thickness was measured by hematoxylin and eosin staining, and a spheroid with a smooth surface was observed under a scanning electron microscope. Finally, compared with the control group, local infusion of paclitaxel nanoparticles could effectively inhibit the proliferation of vascular endothelium in a dose-dependent manner. Local intravascular infusion of paclitaxel nanoparticle suspension can effectively inhibit the proliferation of vascular endothelial cells, and its inhibitory effect increases with the increase of the concentration of nanoparticle suspension. The paclitaxel nanoparticle suspension at a concentration of 30 mg/ml can play a good inhibitory role.