The Use of Murine Infection Models to Investigate the Protective Role of TNF in Central Nervous System Tuberculosis.
Methods in molecular biology (Clifton, N.J.)(2021)
摘要
Tuberculosis of the central nervous system (CNS-TB) is the most severe form of extra-pulmonary tuberculosis that is often associated with high mortality. Secretion of tumor necrosis factor (TNF) has important protective and immune modulatory functions for immune responses during CNS-TB. Therefore, by combining the approaches of aerosol and intracerebral infection in mice, this chapter describes the methods to investigate the contribution of TNF in protective immunity against CNS-TB infection.
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关键词
TNF,Tuberculosis,Infection,Dissemination,CNS,Extra-pulmonary,Brain
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