Parkinson'S Disease With Depression: The Correlations Between Neuroinflammatory Factors And Neurotransmitters In Cerebrospinal Fluid

Background: To explore the changes of neuroinflammatory factors in cerebrospinal fluid (CSF) and their correlation with monoamine neurotransmitters in Parkinson's disease (PD) with depression (PD-D) patients.Methods: Neuroinflammatory factors and neurotransmitters in CSF were measured and compared between PD with no depression (PD-ND) and PD-D groups. The relationship between PD-D and neuroinflammatory factors was studied by binary logistic regression equation, and the related factors of PD-D were adjusted. The correlations of the levels of neuroinflammatory factors and neurotransmitters in PD-D group were analyzed.Results: The levels of tumor necrosis factor (TNF)-alpha in CSF from PD-D group were significantly higher and there were no significant differences in the levels of interleukin-1 beta, prostaglandin (PG) E-2, hydrogen peroxide (H2O2), and nitric oxide (NO). The 24-item Hamilton Depression Scale (HAMD-24) score was positively correlated with the level of TNF-alpha in CSF. Binary logistic regression showed that the OR of CSF TNF-alpha level was 1.035 (95% CI 1.002-1.069). The level of dopamine (DA) in CSF of PD-D group was significantly lower than that in PD-ND group. TNF-alpha level was negatively correlated with DA level in CSF from PD patients (r = -0.320, P = 0.003).Conclusions: Neuroinflammatory factors, especially TNF-alpha, may play an important role in PD-D. It may cause damage to DA neurons and lead to the depletion of DA, which is related to the occurrence and development of PD-D.