Effects of foetal and breastfeeding exposure to methylmercury (MeHg) and retinol palmitate (Vitamin A) in rats: Redox parameters and susceptibility to DNA damage in liver

Helen Tais da Rosa-Silva,Alana Castro Panzenhagen,Pedro Espitia-Pérez, Alexsander Alves Teixeira, Alice Roitman,Roberto Farina Almeida,Luana Heimfarth,José Cláudio Fonseca Moreira

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2020）

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摘要

•Exposure to MeHg promotes redox imbalance and damage to macromolecules.•Vitamin A has no protective effect on MeHg exposure in adulthood.•MeHg generates DNA damage and damage in repairing that damage.•Exposure to MeHg is genotoxic and mutagenic and its effects are intensified in the presence of Vitamin A.

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关键词

Methylmercury,Vitamin A,DNA-damage,Oxidative stress,DNA-repair

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