The Repertoire of Brain Synchronized States Accounts for Stroke Recovery

We demonstrate the first experimental evidence that fluctuations in electroencephalographic (EEG) resting-state connectivity are associated with recovery from stroke. We found that fluctuations in instantaneous brain states, quantified as the variance in EEG phase synchronized states, were correlated with motor-related subscores in the Functional Independence Measure, which estimates the recovery of activities of daily living (ADL) in stroke patients. The results suggest that the dynamic repertoire of spontaneous large-scale phase synchronization networks constrains functional networking and accounts for the ADL recovery.