ATP Impedes the Inhibitory Effect of Hsp90 on Aβ40 Fibrillation

Hongzhi Wang,Max Lallemang,Bianca Hermann,Cecilia Wallin, Rolf Loch,Alain Blanc,Bizan N Balzer,Thorsten Hugel,Jinghui Luo

Journal of Molecular Biology（2021）

引用 14|浏览8

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摘要

•Hsp90 inhibits Aβ fibrillation, while the mechanism remains unclear.•Hsp90 inhibits Aβ fibrillation, particularly in the elongation process.•ATP impedes the inhibitory effect of Hsp90 on Aβ fibrillation.•The atypical ATP-sensitive pathway of Hsp90 might be a feed-back loop against the toxicity of Aβ.

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关键词

Hsp90,ATP,AFM,CD,ThT,ANS,Aβ,WT,GR-LBD,ETC,UPR,PICUP,ER,AMP-PNP,APS

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