Design, Synthesis, Antiproliferative Evaluation, And Molecular Docking Studies Of N-(3-Hydroxyindole)-Appended Beta-Carbolines/Tetrahydro-Beta-Carbolines Targeting Triple-Negative And Non-Triple-Negative Breast Cancer
ACS OMEGA(2020)
摘要
The present manuscript pertains to the design and synthesis of a series of 3-hydroxyindole-substituted beta-carbolines/tetrahydro-beta-carbolines with an aim to explore their antiproliferative structure-activity relationship against breast cancer. The conjugate with an optimum combination of a flexible tetrahydro-beta-carboline core, a tertiary alcoholic group along with a chloro substituent on the indole ring, proved to be the most active compound. It displayed IC50 values of 13.61 and 22.76 mu M against MCF-7 (ER+) and MDA-MB-231 (ER-) cells, respectively. The docking studies were found to be consistent with experimental results owing to the stronger binding affinity of the synthesized conjugates via hydrophobic and H-bonding interactions.
更多查看译文
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络