SIRT3 Deficiency Sensitizes Angiotensin-II-Induced Renal Fibrosis

Xiaomeng Feng
Xiaomeng Feng
Han Su
Han Su
Xiaochen He
Xiaochen He

CELLS, pp. 25102020.

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Abstract:

Background: Sirtuin 3 (SIRT3) has a crucial role in the cardiovascular diseases. Our previous study revealed that SIRT3 knockout (SIRT3KO) promoted cardiac pericyte-fibroblast transition. In this study, we investigated the involvement of pericyte and iron in angiotensin II (Ang-II)-mediated renal fibrosis in the SIRT3KO mice. Methods and ...More

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