Application of “omics” sciences to the prediction of bone metastases from breast cancer: State of the art

Marica Gentile, Antonella Centonza,Domenica Lovero,Raffaele Palmirotta,Camillo Porta,Franco Silvestris,Stella D'Oronzo

Journal of Bone Oncology（2021）

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摘要

•Breast cancer (BC) is the first cause of cancer-related death in women.•Most patients with advanced BC develop bone metastases (BM).•Omics technologies have been applied to identify putative BM “predicting” biomarkers.•Prospective studies are needed before any clinical application of such biomarkers.

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关键词

ADAMTS1,ALP,BALP (BSAP),BC,BM,BTM,BOLCs,CAPG,CCN3,CDH11,CNV,CTGF,CTSK,CTX,CXCL,CXCR,DEGs,DOCK4,DPD,DTC,EMT,ER,ERRα,FAK,FGF,FST,GIPC1,Her,HR,ICAM-1,IGF,IHC,IL,LC/MS/MS,MAF,MDA-MB,miRNAs,MMP1,ncRNAs,NTX,OPG,PDGF,P1CP,P1NP,PlGF,PgR,PRG1,PTH-rP,PYD,RANK,RT-PCR,SILAC-MS,SNPs,SPP1,SREs,TCGA,TGF-β,TNF-α,TRACP-5b,VEGF,ZNF217

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