Repression Of Pum1-Mediated Mrna Decay Activates Translesion Synthesis After Dna Damage

Toshimichi Yamada,Xiaoning Sun,Nobuyoshi Akimitsu

MOLECULAR & CELLULAR ONCOLOGY（2020）

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摘要

Biological roles of Pumilio1 (PUM1) in ubiquitous cells remain unclear. Here we identify 48 degrading target mRNAs by combined analysis of transcriptome-wide mRNA stabilities and the binding of mRNAs. Further analysis revealed that cells respond to DNA damage by inhibiting PUM1-mediated mRNA decay to activate translesion synthesis (46/50).

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关键词

Pumilio, RNA stability, RNA-seq, translesion synthesis

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