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A cysteine peptidase inhibitor from the Orange tree (Citrus sinensis) inhibits periodontitis-induced hone loss by retaining osteoclasts at the macrophage stage.

Natalia Da Ponte Leguizamon, Glaucia Coletto-Nunes,Daniela Morilha Neo-Justino,Vanessa Karine Schneider,Andressa Vilas Boas Nogueira,Rafael Scaf Molon,Flavio Henrique Da Silva,Andrea Soares Da Costa Fuentes,Ulf Holger Lerner,Joni Augusto Cirelli,Pedro Paulo Chaves Souza

JOURNAL OF BONE AND MINERAL RESEARCH（2018）

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