P665 A Genome-Wide Association Study Identifies DSE-FAM26F As a Risk Locus for Ulcerative Colitis

Results: Significant associations were obtained between IBD overall and SNP markers in the genetic regions of MAGI3 (P = 0.002), MAGI2 (P = 0.010), F11R (P = 0.019), and MAGI1 (P = 0.024).Markers in the genetic regions of MAGI2 (P = 0.011) and MAGI1 (P = 0.037) were significantly associated with CD.Additionally, markers in the genetic regions of MAGI3 (P = 0.003), MAGI2 (P = 0.010), and F11R (P = 0.026) showed significant associations to UC. Conclusions: Four out of six investigated TJ-related genes showed association to IBD overall as well as CD and UC.Our findings add further support for a genetically impaired intestinal epithelial barrier as one predisposing factor in the etiology of IBD.In-depth exploration of these TJ-components, may lead to a better understanding of the pathogenic mechanisms underlying IBD.