Short- and Long-term Treatment of Pyridoxamine, an Inhibitor of Advanced Glycation End Products, Attenuates Plateletneutrophil Interactions and Vascular Occlusion in Sickle Cell Disease

Jing Li,Si-Yeon Jeong,Bei Xiong,Alan Tseng, Andrew Mahon, Steven Isaacman,Jaehyung Cho

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY（2019）

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摘要

Sickle cell disease (SCD) is an inherited blood disorder, leading to sickling and hemolysis of red blood cells, activation of intravascular cells, and chronic inflammation. Recurrent vaso-occlusion...

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