Analyses of the performance of the Ebola virus disease alert management system in South Sudan: August 2018 to November 2019.

South Sudan implemented Ebola virus disease preparedness interventions aiming at preventing and rapidly containing any importation of the virus from the Democratic Republic of Congo starting from August 2018. One of these interventions was a surveillance system which included an Ebola alert management system. This study analyzed the performance of this system. A descriptive cross-sectional study of the Ebola virus disease alerts which were reported in South Sudan from August 2018 to November 2019 was conducted using both quantitative and qualitative methods. As of 30 November 2019, a total of 107 alerts had been detected in the country out of which 51 (47.7%) met the case definition and were investigated with blood samples collected for laboratory confirmation. Most (81%) of the investigated alerts were South Sudanese nationals. The alerts were identified by health workers (53.1%) at health facilities, at the community (20.4%) and by screeners at the points of entry (12.2%). Most of the investigated alerts were detected from the high-risk states of Gbudwe (46.9%), Jubek (16.3%) and Torit (10.2%). The investigated alerts commonly presented with fever, bleeding, headache and vomiting. The median timeliness for deployment of Rapid Response Team was less than one day and significantly different between the 6-month time periods (K-W = 7.7567; df = 2; p = 0.0024) from 2018 to 2019. Strengths of the alert management system included existence of a dedicated national alert hotline, case definition for alerts and rapid response teams while the weaknesses were occasional inability to access the alert toll-free hotline and lack of transport for deployment of the rapid response teams which often constrain quick response. This study demonstrates that the Ebola virus disease alert management system in South Sudan was fully functional despite the associated challenges and provides evidence to further improve Ebola preparedness in the country. Author summary The Democratic Republic of Congo announced its tenth outbreak of the Ebola virus disease on 1(st) August 2018. As part of the preparedness measures to prevent and rapidly contain any importation of the virus, South Sudan, a neighbouring country to the Democratic Republic of Congo implemented a surveillance system which included an Ebola alert management system. We analyzed the performance of this system with a view to provide information to inform planning and allocation of resources to the other components of Ebola virus disease preparedness and to understand the key issues and challenges with the system. Our findings show that more than half of the reported alerts did not meet the case definition of the disease, alerts were mainly detected in the high-risk states, the commonest source of alert detection were from health facilities and the community and the most common symptoms presented by the alerts were fever, bleeding, headache, vomiting and weakness/fatigue. This study demonstrates that the Ebola virus disease alert management system in South Sudan was fully functional despite the associated challenges and provided evidence to further improve Ebola preparedness in the country. We recommend that the observed challenges should be urgently addressed.