Amorphous silibinin nanoparticles loaded into porous starch to enhance remarkably its solubility and bioavailability in vivo

Colloids and Surfaces B: Biointerfaces（2021）

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摘要

•Silibinin(SLB) was loaded into porous starch(PS) in the form of nanoparticles (SNPS).•The SNPs had better dissolution properties than free SLB and SLB nanoparticles.•The SNPs has better oral bioavailability than free SLB and SLB nanoparticles.

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关键词

SLB,PS,SN,SNPS,LAP,EE,DL,AGJ,AIJ,SEM,XRD,FTIR,DSC,HPLC,Cmax,AUC,T1/2

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