Green Optimization of the First Steps for the Synthesis of a Novel Surfactant: Towards the Elimination of CMR Solvents and the Drastic Reduction of the Used Solvent Volume

In this report, the first steps of the synthesis of a novel surfactant have been described. Each stage has been optimized to abide by the principles of green chemistry. The replacement of CMR (Carcinogenic, Mutagenic, Reprotoxic) solvents by 4-MTHP (4-methyltetrahydropyran) led to the improvement of the overall yield and to the drastic reduction of the total organic solvent volume used in the process.