Synthesis of New Quinazolin-4-(3H)-one Derivatives and Evaluation of Their Biological Activities

A new series of quinazolin-4-ones are conveniently synthesized in a one-pot procedure from anthranilamide derivatives and aldehydes using p-toluenesulfonic acid as a catalyst. The aim of inserting azo pyridyl and 4-amino benzamide groups in the structure of quinazolin-4-one derivatives is to achieve skeletal appearance with more antibacterial and antifungal properties. Therefore, the biological activities of the synthetic compounds were studied. The results revealed that almost all compounds exhibit antimicrobial activities.