Synthesis, characterization and photophysical properties of novel thiazole substituted pyridine derivatives

Three series of isomeric 2-pyridyl 4-aryl thiazoles have been synthesized by reacting 2/3/4-pyridine thioamides derived from the corresponding nitrites with various 4-substituted phenacyl bromides using Hantzsch thiazole synthesis. Amongst the three isomeric series, 2-pyridyl and 4-pyridyl isomers are found to exhibit better photophysical properties than 3-pyridyl series. 4-Pyridyl isomer with methoxy substituent on phenyl ring is found to exhibit high luminescence quantum yield. The relationship between the structure and the photophysical properties have been studied using DFT calculations.