Facile one-pot synthesis of novel 3-substituted-1, 6-dihydro-1,2,4-triazin-5-(2H)-ones from fatty acid hydrazides and their in-vitro antimicrobial activity

A series of 3-substituted-1,6-dihydro-1,2,4-triazin-5(2H)-ones, have been synthesized using the cyclocondensation reaction of fatty acid hydrazides with 2-chloroacetamide. in N,N-dimethylformamide medium: The structural elucidation of the synthesized compounds is based oil IR, (1)H NMR, mass spectral data and elemental analysis. These compounds have been tested for their in-vitro antibacterial and antifungal activities. The MIC, MBC and MFC have also been determined.