Synthesis of 6-Naphthoxy and 6-(alpha-Cyanobenzyl)-3, 4-Dihydropyrimidin-4-(3 H)-Ones as Potent HIV-1 Inhibitors
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY（2018）
Abstract
A series of novel dihydroalkoxybenzyloxopyrimidines (S-DABOs) derivatives were synthesized as potent inhibitors of human immunodeficiency virus type-1 (HIV-1) through one-pot procedure. The chemical modification, which included the replacement of the 6-arylmethyl in previous S-DABOs with a 6-naphthoxy or 6-(alpha-cyanobenzyl) group, was performed.
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Key words
6-Naphthoxy substituted S-dihydroalkoxybenzyloxopyrimidines,6-(alpha-Cyano-benzyl) substituted S-dihydroalkoxybenzyloxopyrimidines,Human immunodeficiency virus type-1 inhibitor,Synthesis,One-pot procedure
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